The present studies were performed to investigate the interaction of 17,8 -estradiol and human growth hormone(hGH) on the proliferation of human periodontal ligament(hPDL) cell. The independent effects of 17,6 -estradiol and hGH on hPDL cell proliferation were investigated and the effects of hGH on hPDL cell proliferation after 175-estradiol pre-treatment were also investigated. Lastly, the change of hGH receptor expression in hPDL cell after 175 -estradiol pre-treatment were investigated
The obtained results were as follows;
1. The treatment of 17 $ -estradiol or hGH had no significant effects on hPDL cell proliferation.
2. After pre-treatment of 17,8 -estradiol, hGH stimulated the proliferation of the hPDL cell, regardless of hHG concentration.
3. Although there was not hGH receptor in the hPDL cell, hGH receptors were expressed in hPDL cell after more than 6 hours pre-treatment cf 17 $ -estradiol.
4. The effect of hGH on hPDL, cell proliferation was related to the hGH receptor expression. 17,8 -estradiol pre-treatment contributed to the hGH effects on the hPDL cell by stimulating hGHR expression.
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